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It has not been formally released by the U. Environmental Protection Agency and should not at this stage be construed to represent Agency policy. It is being circulated for Zircojia on its technical merit and policy implications.

Zirconia NC 3 somes

Considerably lower incidences of tumors 2 to 4 percent were noted for large-diameter alumina and zirconium oxide fibers following intrapleural administration. Chapter 5 provides acute, subchronic, and chronic toxicity data for laboratory animals as the data relate to noncarcinogenic or systemic effects. Rock wool and slag wool can induce considerable cytotoxicity in V Chinese hamster lung cells, A human tumor cells, and mouse peritoneal macrophages.

The some of average ceramic fiber concentration in air samples from three plants was reported to be 0.

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The of two case reports suggest that inhaled attapulgite can reach the alveoli and that ingested attapulgite is absorbed and eliminated in the urine when consumed in large amounts. Fibrous glass wools and filaments are relatively more water-soluble and less chemical- Zirconia NC 3 somes than mineral wool, although both are susceptible, in varying degrees, to acid and base attack.

Attapulgite, a light cream-colored powder, is chemically inert and its Zirconnia are unaffected by changes in pH. Retained fibers are cleared slowly from the lung. Equivalent masses and s of various glass and asbestos fibers induced comparable cell responses, but the extent of toxicity was primarily dependent on fiber size.

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Airborne concentrations in mining and milling facilities have been found to range between 0. The mineralogic composition varies greatly with the site of origin and the presence eomes other minerals. No other effects or pulmonary tumors were noted. Environmental Release and Fate Emissions of minerals are associated with natural weathering, mining operations, and the use of these materials in secondary products, but no estimates are available for attapulgite.

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In hamsters dosed intratracheally with rock wool 1. Human Health Effects Several cross-sectional morbidity studies of miners and millers indicate increased respiratory symptoms, higher prevalence of pleura!

However, the presence of tremolite-actinolite asbestos precludes a causal relationship between exposure to vermiculite and lung cancer or NMRD. Intraperitoneal administra- tion of polypropylene fibers diameter permissible substitution.

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Unlike inhalation studies, increased incidences of mesotheliomas and sarcomas were noted in rats following intrapleural or intraperitoneal administration of rock wool. NOHS estimated that workers Zircconia exposed to mineral wool in Animal Toxicity No information was available on the acute toxicity of talc, although intratracheal instillation of talc in hamsters resulted in pulmonary toxicity as shown by biochemical and cellular changes.

Human Health Effects Cross-sectional studies with workers exposed to mineral wool indicate skin, eye, and respiratory manifestations similar to those observed in workers exposed to glass fibers.

Zirconia NC 3 somes

Metabolism Various factors influence the deposition of inhaled particles in the respiratory tract; for fibers, these include the aerodynamic equivalent diame- ter D. Erionite has been used for nitrogen retention in fertilizers and concrete aggregate and in road surfacing, but production and use volumes are unavail- able. The corresponding RfD values were 0.

Approximately and million pounds of textile fibers and insulaticr glass wool, respectively, were produced in Based on the weight of evidence from human health effects data and animal toxicity data summarized in Chapter Zirconia NC 3 somes see Tablethe carcinogenicity classification for fibrous glass is Bl and for glass microfibers is B2. Similarly, no information was available on chronic inhalation toxicity.

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The largest end uses of talc are in ceramics and paint; only 5 percent are used in cosmetics. Their physical and chemical properties are deter- mined by their crystal structure, chemical composition, and crystallization habit.

The largest end uses of talc are in ceramics and paint; only 5 Zirconia NC 3 somes are used in cosmetics. Another recer. The strong- est evidence for a causal relationship between exposure to glass wool fibers and NMRD comes from a study conducted in the United States Bayliss et a!. Erionite has been shown to penetrate the pleura! Based on the weight of evidence from human health effects Zriconia and animal toxicity data summarized in Chapter 9 see Tablethe carcinogenicity classification for fibrous glass is Bl and for glass microfibers is B2.

The melted compound is blown to form fibers used primarily for high-temperature insulation.

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Long fibers 10 ym of small diameter 0. Also unavailable were information on airborne concentrations in manufacturing Zjrconia and ambient air, NOHS and NOES estimates of worker exposure, and esti- mates of consumer exposure. The principal route of exposure to fibers is inhalation. Simi- larly, estimates of airborne concentrations in mining facilities and ambient air, as well as worker and consumer exposure, were not reported. Environmental Release and Fate Estimates of environmental release of talc are not available.

Metabolism Factors affecting retention and clearance of mineral wool fibers are similar to those discussed for fibrous glass with similar dimensions. Pulmonary clearance is facilitated by mucociliary activity and eliminated in the feces via the gastrointestinal tract.

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Slmes at: international symposium on man-made mineral fibres in the working Zirconiia October; Copenhagen, Denmark. Little, if any, talc is absorbed from the gastrointestinal tract of rats, guinea pigs, mice, and hamsters following oral intubation. Attapulgite finds a wide commercial application in both absorbent and jelling or thickening agents due, in part, to its sorptive and colloidal properties.

Lung cancer mortality among the three combined cohorts by process and time since first exposure Respiratory cancer mortality by exposure to small-diameter glass wool fibers and time since Zirconia NC 3 somes employment Selected cancer mortality for U.

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